€3,651.00 €3,103.35
TRIM33 (TIF1-?) is a multi-domain regulator of transcription. It contains a RING domain with E3 ubiquitin ligase activity, two B-boxes, a coiled-coil domain, a PHD domain, and a bromodomain. TRIM33 is necessary for embryogenesis, and mice homozygous for TRIM33 knock-out do not survive to embryonic day 9.5.{24403} TRIM33 is targeted to DNA by its tandem PHD and bromodomain which bind histone 3 at trimethylated lysine 9 (H3K9me3) and acetylated lysine 18 (H3K18ac), respectively.{24405} TRIM33 represses TGF-? signaling by sequestering SMAD2/3, and by ubiquitinating SMAD4.{24402,24407,24406} The TRIM33-SMAD2/3 complex upregulates transcription at sites of H3K9 trimethylation. During the DNA damage response, TRIM33 targets Amplified in Liver Cancer 1 (ALC1) to sites of DNA damage.{24404} Deletion of either the PHD or bromodomain of TRIM33 prevents localization of TRIM33 to sites of DNA damage.{24404} This protein product contains the PHD and bromodomains of TRIM33.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol |
| Purity | ≥80% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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