Malformin C

Malformin C

CAT N°: 21613
Price:

From 342.00 290.70

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.{33545} Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).{33544} It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).{33544} Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.{33546}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1?2)-disulfide
  • Correlated keywords
    • aspergillus niger FKI-2342 HCT115
  • Product Overview:
    Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.{33545} Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).{33544} It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).{33544} Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.{33546}

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