Irisin Polyclonal Antibody

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • Western blots blotting WBs ELISAs enzymes immunoassays immunosorbents EIAs antibodies antiseras antiserums immunoblotting PGC-1a PGC-1alpha PGC-1.alpha. PGC-1? 1a 1alpha 1.alpha. 1? peroxisomes proliferators proliferator-activated activated receptors C coactivators fibronectins types-III types-3 types III 3 FNDC5 domains containing proteins 5 insulin weights losses metabolic metabolisms transcriptional co-activators regulates regulations mitochondrial biogenesis functions obesity resistance diabetes expressions membranes stimulated muscles exercises proteolytically cleaved cleavages secretes secreted secretions hormones peptides Greek Greece goddess Iris white adipose tissues fats WAT brown BAT anti anti-obesity anti-diabetic diseases states mouse mice exogenous levels uncoupling UCP1 thermogenesis heats expenditures physiological responses induced inductions effects increases disorders bacterially expressed
• Product Overview:
  Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1? (PGC-1?), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by increased expression of the PGC1-? protein in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose tissue (WAT) to brown adipose tissue (BAT).{20433} An increase in BAT results in anti-obesity and anti-diabetic metabolic states in mice. Exogenous irisin levels in mice leads to higher levels of the uncoupling protein UCP1, which results in an increase in thermogenesis and heat expenditure.{21923} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and metabolic disorder. Cayman’s irisin polyclonal antibody detects a 13 kDa band from bacterially expressed irisin protein (Item No. 11451), and a 32 kDa band from deglycosylated human serum.