Lincomycin

Lincomycin

CAT N°: 21526
Price:

From 196.00 166.60

Lincomycin is a lincosamide antibiotic originally isolated from S. lincolnensis.{22680,60231} It is active against Gram-positive bacteria, including various strains of S. aureus, S. epidermidis, S. pneumoniae, and S. pyogenes (MICs = 0.2-3.2, 0.4-1.8, 0.01-0.8, and 0.04-0.8 µg/ml, respectively).{60231} Lincomycin selectively inhibits protein synthesis in purified ribosomes from S. aureus over E. coli (IC50s = 0.03 and 1.7 µg/ml, respectively, in cell-free assays).{60232} It is protective against development of mastitis in a mouse model of acute mastitis induced by S. aureus with a 50% protective dose (PD50) value of 3.5 mg/kg.{60233} Formulations containing lincomycin have been used in the treatment of Gram-positive bacterial infections.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-?-D-galacto-octopyranoside
  • Correlated keywords
    • 12768-69-3 16977-76-7 Cillimycin Jiemycin Lincolcina Lincolnensin Lincomycin-A Medoglycine U-10,149A 10149A U10149 U10149A anti-biotic Staphylococcus Streptococcus Streptomyces Escherichia
  • Product Overview:
    Lincomycin is a lincosamide antibiotic originally isolated from S. lincolnensis.{22680,60231} It is active against Gram-positive bacteria, including various strains of S. aureus, S. epidermidis, S. pneumoniae, and S. pyogenes (MICs = 0.2-3.2, 0.4-1.8, 0.01-0.8, and 0.04-0.8 µg/ml, respectively).{60231} Lincomycin selectively inhibits protein synthesis in purified ribosomes from S. aureus over E. coli (IC50s = 0.03 and 1.7 µg/ml, respectively, in cell-free assays).{60232} It is protective against development of mastitis in a mouse model of acute mastitis induced by S. aureus with a 50% protective dose (PD50) value of 3.5 mg/kg.{60233} Formulations containing lincomycin have been used in the treatment of Gram-positive bacterial infections.

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