DCP-LA

DCP-LA

CAT N°: 21375
Price:

122.00 103.70

DCP-LA is a derivative of linoleic acid (Item No. 90150) and a potent activator of PKC?.{41891} It activates PKC? with a greater than 7-fold stronger potency over PKC?, ?I, ?II, ?, ?, ?, ?, and ? in a cell-free assay. DCP-LA activates PKC in PC12 cells in a concentration-dependent manner, an effect that is blocked by the PCK inhibitor bisindolylmaleimide I (Item Nos. 13298 | 21180) and a PCK?-selective peptide inhibitor. It decreases intracellular levels of amyloid-? (A?) in Neuro2 neuroblastoma cells transfected with human APPSwe/PS1?9.{41892} DCP-LA also stimulates hippocampal glutamate release, striatal dopamine release, and hypothalamic serotonin release in rat brain slices in a PKC- and ?7-containing nicotinic acetylcholine receptor-dependent manner.{41893} In vivo, DCP-LA (3 mg/kg, i.p.) prevents synaptic loss and amyloid plaque formation and decreases escape latency in the Morris water maze in the 5XFAD transgenic mouse model of Alzheimer’s disease.{41894}

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