NCH-51

NCH-51

CAT N°: 21234
Price:

From 128.00 108.80

NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.{41830} It increases acetylation of histone H4 and ?-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM).{41831,41832} NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-?, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.{41830}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid
  • Correlated keywords
    • NCH51 HDAC H-4 HCT-116 HIV1 ACH2 TNF? XXII
  • Product Overview:
    NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.{41830} It increases acetylation of histone H4 and ?-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM).{41831,41832} NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-?, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.{41830}

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