€768.00 €652.80
Voltage-dependent L-type calcium channel subunit ?-4 (Cav?4) is a regulatory subunit of Cav1 and Cav2 voltage-gated calcium channels that modulates channel gating and expression, as well as interactions with regulatory G proteins and kinases.{60997} It is composed of N-terminal, SH3, guanylate kinase, and C-terminal domains, as well as a HOOK region. Cav?4 is primarily expressed in the brain and spinal cord but has also been found in kidney, nerve endings at the neuromuscular junction, ovary, skeletal muscle, T cells, and testis and localizes to the cytosol, plasma membrane, and nucleus.{60997,60998,65159} It modulates channel gating and expression, as well as interactions with regulatory G proteins and kinases via binding of the ?-interaction domain (AID) of the Cav? subunit.{60997} Knockout of Cacnb4, the gene encoding Cav?4, prevents the development of Purkinje neurons in mice.{65160} Mutations in CACNB4 have been found in patients with epilepsy or episodic ataxia.{65161} Cayman’s Cav?4 Calcium Channel Monoclonal Antibody can be used for immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes Cav?4 at approximately 58 kDa from human, mouse, and rat samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | Synthetic peptide from rat Cav?4 amino acids 458-474 |
| Clone | S10-7 |
| Isotype | IgG1 |
| Application(s) | IF, WB, IHC, ICC |
| Formulation | 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, with 50% glycerol and 0.09% sodium azide |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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