Dorsomorphin (hydro<wbr/>chloride)

Dorsomorphin (hydrochloride)

CAT N°: 21207
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From 48.00 40.80

Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKC?, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin, at 10 ?M, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}

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