Chk2 Inhibitor

Chk2 Inhibitor

CAT N°: 21184
Price:

From 365.00 310.25

Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM).{48513} It is selective for Chk2 over Chk1 (IC50 = 220.4 nM). It inhibits Chk2 autophosphorylation at the serine in position 516 in non-cancerous 184B5 cells that contain wild-type p53 and in MDA-MB-231 cells that contain mutated p53 when used at concentrations ranging from 0.1 to 30 µM. Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the production of TNF-? in LPS-stimulated THP-1 cells (IC50s = 3.5 and 8.2 µM, respectively).{48514} Chk2 inhibitor also inhibits the growth of CEM leukemia T cells (GI50 = 1.73 µM).

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