Leukotriene B<sub>5</sub>

Leukotriene B5

CAT N°: 21110
Price:

From 213.00 181.05

Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.{36392,36393,551,2238,330} It is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908) formed through the 5-lipoxygenase (5-LO) pathway.{719} LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.{36392} In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells.{36393} LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 (Item No. 20110).{551,2238,330}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5S,12R-dihydroxy-6Z,8E,10E,14Z,17Z-eicosapentaenoic acid
  • Correlated keywords
    • 195324-71-1 LTB-5 4 LT Tm-1 5,12-DiHEPE 5LO
  • Product Overview:
    Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.{36392,36393,551,2238,330} It is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908) formed through the 5-lipoxygenase (5-LO) pathway.{719} LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.{36392} In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells.{36393} LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 (Item No. 20110).{551,2238,330}

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