N-Butyldeoxy<wbr/>nojirimycin (hydro<wbr/>chloride)

N-Butyldeoxynojirimycin (hydrochloride)

CAT N°: 21065
Price:

From 55.00 46.75

NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and ?-glucosidase 2 (IC50s = 32 and 81 ?M, respectively, for the rat recombinant enzymes).{38202} It also increases the activity of wild-type acid ?-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells expressing the human enzymes when used at a concentration of 10 µM.{38203} NB-DNJ also inhibits HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs; IC50s = 282 and 211 ?M, respectively).{38204} Formulations containing NB-DNJ have been used in the treatment of Gaucher disease, an inborn error of metabolism characterized as a lysosomal storage disorder resulting from substantial deficiency of ?-glucosidase.

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