24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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From €48.00 €40.80
Nifekalant is a class III antiarrhythmic agent.{64356} It inhibits the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM) and prolongs cardiac action potential duration (APD) in isolated dog Purkinje fibers when used at concentrations of 1 and 3 µg/ml.{64356,24505} Nifekalant (3 mg/kg) inhibits arrhythmias induced by programmed electrical stimulation (PES) in dogs post myocardial infarction.{64357} It increases atrial and ventricular effective refractory periods (ERPs) in anesthetized dogs.{64358} Nifekalant also inhibits human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993} Formulations containing nifekalant have been used in the treatment of arrhythmias and ventricular tachycardia.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 130656-51-8 |
| Molecular formula | C19H27N5O5 • HCl |
| Smiles | OCCN(CCNC1=CC(N(C)C(N1C)=O)=O)CCCC2=CC=C([N+]([O-])=O)C=C2.Cl |
| Molecular weight | 441,9 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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