GSK2981278

GSK2981278

CAT N°: 20974
Price:

From 55.00 46.75

GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor ? (ROR?; IC50 = 17 nM in a transactivation assay).{63393} It is selective for ROR? over ROR?.{34217} GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing conditions (IC50 = 3.2 nM). Topical application of GSK2981278 (1% ointment) reduces dermal symptoms in a mouse model of psoriasis induced by imiquimod (Item No. 14956).

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