17?-Estradiol

17?-Estradiol

CAT N°: 20776
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60.00 51.00

17?-Estradiol is the natural optical isomer of 17?-estradiol (Item No. 10006315), the major estrogen secreted by the premenopausal ovary. 17?-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17?-estradiol.{24968} It can inhibit 5?-reductase, which plays a role in regulating hair growth. 17? -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.{24968,13837}

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