Isoxsuprine (hydro<wbr/>chloride)

Isoxsuprine (hydrochloride)

CAT N°: 20688
Price:

From 55.00 46.75

Isoxsuprine is an adrenergic receptor modulator that has ?-adrenergic receptor (?-AR) antagonist and ?-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an ?-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the ?-AR antagonist propranolol (Item Nos. 23349 | 17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-hydroxy-?-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-benzenemethanol, monohydrochloride
  • Correlated keywords
    • 395-28-8 34233-88-0 34331-89-0 adrenergic ?-adrenergic b-adrenergic uterine anti-nociceptive preterm labor dilavase divadilan duvadilan duviculine isolait isoxsuprin isoxsuprine navilox suprilent suprox-sr tidilan vadosilan vasodilan vasoplex vasotran
  • Product Overview:
    Isoxsuprine is an adrenergic receptor modulator that has ?-adrenergic receptor (?-AR) antagonist and ?-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an ?-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the ?-AR antagonist propranolol (Item Nos. 23349 | 17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.

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