Methoxy-X04

Methoxy-X04

CAT N°: 20476
Price:

48.00 40.80

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-? (A?) to detect and quantify plaques, tangles, and cerebrovascular amyloid.{38022} It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar ?-sheet deposits and is used to image A? plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer’s disease.{38022,38023} For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.{38023} Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.{38023}

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