Dimethylamino Parthenolide

Dimethylamino Parthenolide

CAT N°: 20436
Price:

From 196.00 166.60

Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-?B and a derivative of parthenolide (Item No. 70080).{31980} It inhibits the binding of the p65 subunit of NF-?B to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine (Item No. 20261), NADPH oxidase inhibitor apocynin (Item No. 11976), or RIP1 kinase inhibitor necrostatin-1 (Item No. 11658). DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1aR,4E,7aS,8R,10aS,10bR)-8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
  • Correlated keywords
    • dimethylaminoparthenolide LC1 NF?B anti-oxidant RIP-1 necrostatin1 MDAMB-231 MDA-MB231 MDAMB231 870677-05-7
  • Product Overview:
    Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-?B and a derivative of parthenolide (Item No. 70080).{31980} It inhibits the binding of the p65 subunit of NF-?B to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine (Item No. 20261), NADPH oxidase inhibitor apocynin (Item No. 11976), or RIP1 kinase inhibitor necrostatin-1 (Item No. 11658). DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.

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