DL-Mevalono<wbr/>lactone

DL-Mevalonolactone

CAT N°: 20348
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From 74.00 62.90

DL-Mevalonolactone is the ?-lactone form of mevalonic acid, a precursor in the mevalonate pathway.{36829} It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria.{36830} DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes.{36831} Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.{36830}

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