AZD 1208

AZD 1208

CAT N°: 20235
Price:

From 48.00 40.80

AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively).{32021} It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice.{32021} It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110? inhibitors, respectively.{32019,32020}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1′-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
  • Correlated keywords
    • AZD1208 pan-pim proto-oncogene MOLM-16 megakaryoblastic leukemia mTOR p110a pim 1 2 3
  • Product Overview:
    AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively).{32021} It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice.{32021} It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110? inhibitors, respectively.{32019,32020}

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