SU 4312

SU 4312

CAT N°: 20213
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From 48.00 40.80

SU 4312 is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 ?M, respectively).{32035} It demonstrates IC50 values >100 ?M at EGFR, HER2, and IGF-1R.{32035} SU 4312 has been shown to inhibit VEGF-dependent angiogenesis in a zebrafish assay (IC50 = 1.8 µM) without affecting normal cells.{32036} SU 4312 has also been shown to prevent MPP+-induced neuronal apoptosis in vitro, as well as to decrease MPTP-induced loss of dopaminergic neurons, reduce expression of mRNA for tyrosine hydroxylase, and impair swimming behavior in zebrafish.{32034}

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