20-<wbr/>carboxy Leukotriene B<sub>4</sub>

20-carboxy Leukotriene B4

CAT N°: 20180
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From 262.00 222.70

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.{377} LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ?-oxidation products.{1032} The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.{399}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraene-1,20-dioic acid
  • Correlated keywords
    • leukotrienes metabolites 20-carboxy-LTB4
  • Product Overview:
    20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.{377} LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ?-oxidation products.{1032} The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.{399}

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