Leukotriene B<sub>4</sub>

Leukotriene B4

CAT N°: 20110
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Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.{521,719,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10?10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.{329} At higher concentrations, (1.0 x 10?7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.{329,82}

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