From €55.00 €46.75
Pelargonidin is an anthocyanidin that has been found in P. granatum and has diverse biological activities.{61058,61059,61060,61061} It scavenges superoxide anions in cell-free assays (IC50 = 130 µg/ml) and inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC50 = 85 µM).{61058} Pelargonidin (3 mg/kg) reduces serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte apoptosis, and hepatic levels of IL-1?, IL-6, TNF-?, and TGF-? in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024).{61059} It increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia.{61060} Pelargonidin (0.04-0.4 mg/kg) reduces serum levels of nitric oxide (NO), TNF-?, and IL-6 and increases renal myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis.{61061} It also decreases escape latency in the Morris water maze, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal acetylcholinesterase (AChE) activity in a rat model of Alzheimer’s disease induced by amyloid-? 25-35 (A? (25-35); Item No. 24155).{61062}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 134-04-3 |
| Molecular formula | C15H11O5 • Cl |
| Smiles | OC1=CC(O)=C(C=C(O)C(C2=CC=C(O)C=C2)=[O+]3)C3=C1.[Cl-] |
| Molecular weight | 306,7 |
| Custom code | 2907.29 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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