Aliskiren (hemi<wbr>fumarate)

Aliskiren (hemifumarate)

CAT N°: 19640
Price:

From 48.00 40.80

Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme).{31535} Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.{61205} It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.{61206} Formulations containing aliskiren have been used in the treatment of hypertension.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?S,?S,?S,?S)-?-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-?-hydroxy-4-methoxy-3-(3-methoxypropoxy)-?,?-bis(1-methylethyl)-benzeneoctanamide, 2E-butenedioate
  • Correlated keywords
    • CGP60536 CGP 60536B CGP60536 B rasilez tekturna non-peptide S3 S-3 angiotensin SPP100 CGP60536B hemi-fumarate
  • Product Overview:
    Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme).{31535} Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.{61205} It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.{61206} Formulations containing aliskiren have been used in the treatment of hypertension.

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