Cobimetinib

Cobimetinib

CAT N°: 19563
Price:

From 74.00 62.90

Cobimetinib is a potent, orally available inhibitor of MEK1 (IC50 = 4.2 nM).{27940,32043} It shows more than 100-fold selectivity for MEK when tested against a panel of more than 100 serine-threonine and tyrosine kinases. Cobimetinib induces differentiation and apoptosis in cancer cell lines and is more effective when combined with additional inhibitors, like PLX4032 (Item No. 10618).{32043,32044,32045}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-methanone
  • Correlated keywords
    • 1029872-29-4 GDC0973 RG7420 XL-518 cotellic MEK1
  • Product Overview:
    Cobimetinib is a potent, orally available inhibitor of MEK1 (IC50 = 4.2 nM).{27940,32043} It shows more than 100-fold selectivity for MEK when tested against a panel of more than 100 serine-threonine and tyrosine kinases. Cobimetinib induces differentiation and apoptosis in cancer cell lines and is more effective when combined with additional inhibitors, like PLX4032 (Item No. 10618).{32043,32044,32045}

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