4?-hydroxy Cholesterol

4?-hydroxy Cholesterol

CAT N°: 19518
Price:

From 55.00 46.75

4?-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4?-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7?-hydroxylation, which is the rate-limiting step for further conversion into bile acids.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • cholest-5-ene-3?,4?-diol
  • Correlated keywords
    • 879877-81-3 886027-17-4 CYP3A endogenous marker cytochrome P4503A CYP3A5 isoforms (CYP)3A4
  • Product Overview:
    4?-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4?-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7?-hydroxylation, which is the rate-limiting step for further conversion into bile acids.

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