AST-487

AST-487

CAT N°: 19477
Price:

From €49.00 €41.65

AST-487 is an inhibitor of RET (IC50 = 0.88 µM), FLT3 (Ki = 0.52 µM), KDR (IC50 = 0.17 µM), c-Abl (IC50 = 0.02 µM), and c-Kit (IC50 = 0.5 µM).{31675,31676} It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations.{31675} In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth.{31675} It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.{31675}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N’-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-urea
  • Correlated keywords
    • 1069112-48-6 AST487 NVPAST487 NVP-AST487 NVPAST-487 RET KDR c-Abl auto-phosphorylation NIH-3T3 MTC FLT3 c-Kit Fms tyrosine cAbl cKit FLT-3 FLT3ITD bearing internal-tandem duplication MTCTT anti-proliferative multikinase
  • Product Overview:
    AST-487 is an inhibitor of RET (IC50 = 0.88 µM), FLT3 (Ki = 0.52 µM), KDR (IC50 = 0.17 µM), c-Abl (IC50 = 0.02 µM), and c-Kit (IC50 = 0.5 µM).{31675,31676} It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations.{31675} In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth.{31675} It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.{31675}

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