CBL0137 (hydro<wbr>chloride)

CBL0137 (hydrochloride)

CAT N°: 19373
Price:

163.00 138.55

Curaxins are small molecules that simultaneously activate p53 and inhibit NF-?B without causing detectable genotoxicity.{30977} CBL0137 is a water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-?B with an EC50 value of 0.47 µM.{30977} It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-?B and promoting cancer cell death.{30977} CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. 11690) in preclinical models of pancreatic cancer.{30977,30976}

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