Thiostrepton

Thiostrepton

CAT N°: 19200
Price:

97.00 82.45

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself.{24929,24931} Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells.{24929} These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.{31116}

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