CP 673,451

CP 673,451

CAT N°: 19170
Price:

From 66.00 56.10

CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor ? (PDGFR?) kinase with an IC50 value of 1 nM.{30922} It also inhibits the PDGFR? kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.{30922} In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.{30922,30923,30921}

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