Gemfibrozil 1-O-?-<wbr/>Glucuronide

Gemfibrozil 1-O-?-Glucuronide

CAT N°: 19080
Price:

From 365.00 310.25

Gemfibrozil 1-O-?-glucuronide is a major metabolite of gemfibrozil (Item No. 14835) that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7.{37643} Gemfibrozil 1-O-?-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan (Item No. 14178) in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).{37644,37645}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate], ?-D-glucopyranuronic acid
  • Correlated keywords
    • 1438398-30-1 CYP450 CYP-2C8 OATP-1B1 UGT2B7
  • Product Overview:
    Gemfibrozil 1-O-?-glucuronide is a major metabolite of gemfibrozil (Item No. 14835) that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7.{37643} Gemfibrozil 1-O-?-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan (Item No. 14178) in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).{37644,37645}

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