3-Bromopyruvic Acid

3-Bromopyruvic Acid

CAT N°: 19068
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3-Bromopyruvic Acid (3-BP) is an alkylating agent and an antimetabolite of pyruvate that is metabolized through glutathione conjugation.{34038,34035} It decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers.{43142,34037} 3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks.{43142}

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