SB-207266

SB-207266

CAT N°: 18778
Price:

From 48.00 40.80

The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.{34073, 34070} In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production.{34070} In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis.{34073, 34072, 34071} In a dog model, SB-207266 (0.1–100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg.{34073} SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure.{34069}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
  • Correlated keywords
    • SB207266 5-HT4 5HT4 5-hydroxy tryptamine 5HT c-AMP COS-7 serlipet
  • Product Overview:
    The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.{34073, 34070} In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production.{34070} In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis.{34073, 34072, 34071} In a dog model, SB-207266 (0.1–100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg.{34073} SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure.{34069}

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