ALK-IN-1

ALK-IN-1

CAT N°: 18775
Price:

From 102.00 86.70

ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-?chloro-?N2-?[4-?[4-?(dimethylamino)?-?1-?piperidinyl]?-?2-?methoxyphenyl]?-?N4-?[2-?(dimethylphosphinyl)?phenyl]?-2,?4-?pyrimidinediamine
  • Correlated keywords
    • AP-26113 ALK anaplastic anticancer lymphoma kinase Karpas299 AP26113 ALKIN1 ALKIN-1 ALK-IN1 U-937
  • Product Overview:
    ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}

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