CCT251545

CCT251545

CAT N°: 18761
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From 74.00 62.90

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM).{34178} It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.{30162} Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression.{30162} It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.{34178,30162}

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