Dimethyl DL-Glutamate (hydro<wbr>chloride)

Dimethyl DL-Glutamate (hydrochloride)

CAT N°: 18602
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From 102.00 86.70

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles.{24138} Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes.{30318,30315} It also potentiates the insulinotropic potential of glyburide (Item No. 15009) and glucagon-like peptide 1.{30318,30315} Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in ?-cells.{30316,30320} However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.{30319,30317}

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