ML-178

ML-178

CAT N°: 18527
Price:

From 48.00 40.80

Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through four of the S1P receptors (S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8). Binding of S1P to S1P4 activates ERK, MAPK, and PLC downstream signal transduction pathways. ML-178 activates S1P4 with an EC50 value of 46.3 nM and is inactive against S1P1, S1P2, S1P3, and S1P5 (EC50s = >50 µM) and has no effect against a panel of additional receptors, transporters, and ion channels.{29786}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-pyridine
  • Correlated keywords
    • ML178 CID44620892 CYM50179 SID87544119 agonist S1P4 S1P-4 sphingosine-1-phosphate sphingosine phospate
  • Product Overview:
    Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through four of the S1P receptors (S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8). Binding of S1P to S1P4 activates ERK, MAPK, and PLC downstream signal transduction pathways. ML-178 activates S1P4 with an EC50 value of 46.3 nM and is inactive against S1P1, S1P2, S1P3, and S1P5 (EC50s = >50 µM) and has no effect against a panel of additional receptors, transporters, and ion channels.{29786}

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