NASPM (hydro<wbr>chloride)

NASPM (hydrochloride)

CAT N°: 18453
Price:

From 37.00 31.45

NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide, trihydrochloride
  • Correlated keywords
    • 122306-11-0 1-naphthyl acetyl spermine Joro spider toxin GluR-2 HCI AMPA kainate-induced Ca2+
  • Product Overview:
    NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}

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