A-77-01

A-77-01

CAT N°: 18396
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From 60.00 51.00

A-77-01 is a potent inhibitor of the TGF-?1 receptor ALK5 (IC50 = 25 nM).{31358} It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-? on lung epithelial Mv1Lu cells.{31358} It completely blocks phosphorylation of SMAD2 by TGF-? in human keratinocyte HaCaT cells at 1 µM. A-77-01 prevents morphological and gene expression changes characteristic of epithelial-to-mesenchymal transition in NMuMG cells treated with TGF-?.{31358}

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