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The Arabidopsis shaggy-related kinases (ASKs) are plant kinases that are structurally similar to a Drosophila kinase, shaggy, which has key roles in development. ASKs are also similar to glycogen synthase kinase 3 isoforms, which are found in plants as well as animals. Bikinin is an inhibitor of several ASK isoforms when given at a concentration of 10 µM.{30819} After bikinin treatment, residual kinase activity was less than 10% for ASK?, ?, ?, ?, ?, ?, and 20% for ASK?, while isoforms ? and ? were not affected. Bikinin has little or no direct effect on a wide range of other kinases.{30819} By inhibiting ASKs, bikinin activates signaling induced by the brassinosteroid, brassinolide.{30819} Bikinin blocks the phosphorylation of SnRK2.3 by ASK? (also known as BIN2), upregulating signaling through abscisic acid (Item No. 10073).{30817} Bikinin has been used to study the role of ASK-modulated brassinosteroid signaling in wheat and in viral infection of plants.{30816,30820,30818}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 188011-69-0 |
| Molecular formula | C9H9BrN2O3 |
| Smiles | BrC1=CC=C(NC(CCC(O)=O)=O)N=C1 |
| Molecular weight | 273,1 |
| Custom code | 2933.39 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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