Amidepsine A

Amidepsine A

CAT N°: 17774
Price:

From 402.00 341.70

Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 10.2 µM in rat liver microsomes).{29217} It inhibits triacylglycerol formation in Raji cells with an IC50 value of 15.5 µM.{29217}

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