PF-431396

PF-431396

CAT N°: 17665
Price:

From 48.00 40.80

Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively).{28820} In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.{28821}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide
  • Correlated keywords
    • 1435934-28-3 871811-91-5 inhibitor focal adhesion FAK proline-rich tyrosine kinase PYK2 osteoporosis bone growth osteoblast PF431396 dual inhibit biochemical related research
  • Product Overview:
    Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively).{28820} In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.{28821}

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