GS-9973

GS-9973

CAT N°: 17653
Price:

From 54.00 45.90

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcR? chains and mediates downstream signaling related to platelet function and inflammation.{24052} GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases.{28699} In conjunction with the PI3K? inhibitor CAL-101 (Item No. 15279), it has been used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations.{28700}

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