BMS 493

BMS 493

CAT N°: 17418
Price:

From 66.00 56.10

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation.{20155,20156} BMS 493 is a pan-RAR inverse agonist that blocks RAR? activity with an IC50 value of 114 nM.{30013,30014} In all RAR types (RAR?, RAR?, and RAR?), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.{30016,28461} BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.{30013,30017,30012,30015}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid
  • Correlated keywords
    • pan-RAR BMS204493 panRAR inverse agonist nuclear retinoic acid receptor BMS493 RAR? RARa RAR-? RAR-a
  • Product Overview:
    Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation.{20155,20156} BMS 493 is a pan-RAR inverse agonist that blocks RAR? activity with an IC50 value of 114 nM.{30013,30014} In all RAR types (RAR?, RAR?, and RAR?), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.{30016,28461} BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.{30013,30017,30012,30015}

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