SU 5614

SU 5614

CAT N°: 17410
Price:

48.00 40.80

SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 ?M). SU 5614 also inhibits C-KIT, VEGFR, and PDGFR? in vitro (IC50s = 0.03, 0.46, and 0.36 ?M, respectively).

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