GDC-0032

GDC-0032

CAT N°: 17387
Price:

From 55.00 46.75

GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms ?, ?, and ? (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3K?.{31881} It is over 1,000-fold selective for p100? over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.{31880,31881,31882}

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