A-66

A-66

CAT N°: 17382
Price:

From 54.00 45.90

A-66 is a potent, selective inhibitor of the PI3K isoform p110? (IC50 = 32 nM in a cell-free assay).{32579} It displays over 100-fold selectivity for p110? over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice.{32579} It also impairs all measures of in vivo insulin action in mice.{32580} A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.{31648}

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