GSK2636771

GSK2636771

CAT N°: 17380
Price:

From 66.00 56.10

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are four isoforms (p110?, p110?, p110?, and p100?), and a p85 regulatory subunit. GSK2636771 is an orally bioavailable inhibitor of PI3K p110?.{30758} At 1-10 µM, it decreases cell viability and Akt phosphorylation in p100?-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines.{29910}

We also advise you