Coenzyme Q<sub>2</sub>

Coenzyme Q2

CAT N°: 17327
Price:

From 71.00 60.35

Coenzyme Q10 (Item No. 11506) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP.{20670} In its reduced form, it acts as an antioxidant.{20670} Coenzyme Q2 (CoQ2) is a biosynthetic precursor to the electron transport chain cofactor CoQ10 (Item No. 11506) and an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase.{30591,24936} It is an electron acceptor that accepts electrons from mitochondrial complex I. CoQ2 inhibits the proliferation of BALL-1 human B cell acute lymphoblastic leukemia cells (IC50 = 20 µM) and induces apoptosis in Huh7 and HepG2 hepatoma cells when used at a concentration of 100 µM.{30186} It increases the production of reactive oxygen species (ROS) in BALL-1 cells but inhibits ROS production in mitochondrial membranes derived from bovine heart when used in combination with the mitochondrial complex I inhibitors rotenone (Item No. 13995), piericidin A (Item No. 15379), or rolliniastatin 1 or -2.{30186,24936} CoQ2 increases the production of hydrogen peroxide in isolated rabbit heart mitochondria and decreases it in isolated rabbit liver mitochondria.{66215}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-?[(2E)?-?3,?7-?dimethyl-?2,?6-?octadien-?1-?yl]?-?5,?6-?dimethoxy-?3-?methyl-2,?5-?cyclohexadiene-?1,?4-?dione
  • Correlated keywords
    • 7704-04-3 precursor CoQ10 Q-10 Q-2 Co-Q isoprenoid co-enzyme BALL1 Huh-7 Hep-G2 HepG-2
  • Product Overview:
    Coenzyme Q10 (Item No. 11506) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP.{20670} In its reduced form, it acts as an antioxidant.{20670} Coenzyme Q2 (CoQ2) is a biosynthetic precursor to the electron transport chain cofactor CoQ10 (Item No. 11506) and an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase.{30591,24936} It is an electron acceptor that accepts electrons from mitochondrial complex I. CoQ2 inhibits the proliferation of BALL-1 human B cell acute lymphoblastic leukemia cells (IC50 = 20 µM) and induces apoptosis in Huh7 and HepG2 hepatoma cells when used at a concentration of 100 µM.{30186} It increases the production of reactive oxygen species (ROS) in BALL-1 cells but inhibits ROS production in mitochondrial membranes derived from bovine heart when used in combination with the mitochondrial complex I inhibitors rotenone (Item No. 13995), piericidin A (Item No. 15379), or rolliniastatin 1 or -2.{30186,24936} CoQ2 increases the production of hydrogen peroxide in isolated rabbit heart mitochondria and decreases it in isolated rabbit liver mitochondria.{66215}

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