NPPB

NPPB

CAT N°: 17292
Price:

From 83.00 70.55

NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist.{28152,23789,28153} It has been shown to activate the GPR35-G?i/o and GPR35-G?16 pathways in HEK293 cells, inducing intracellular calcium mobilization.{28153} NPPB has protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.{28154}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-nitro-2-[(3-phenylpropyl)amino]-benzoic acid
  • Correlated keywords
    • chloride channel blocker GPR35 agonist uncoupler mitochondrial ATP biochemical ion pump biology G?i/o G?16 pathway HEK293 cells intracellular calcium mobilization protonophoric activity synthesis phagocyte Hoechst 144 Hoechst144 Hoe144
  • Product Overview:
    NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist.{28152,23789,28153} It has been shown to activate the GPR35-G?i/o and GPR35-G?16 pathways in HEK293 cells, inducing intracellular calcium mobilization.{28153} NPPB has protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.{28154}

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